Comparison of Squamous Cell Carcinoma Tumors With or Without Horn Presentation
abstract
This abstract is available on the publisher's site.
Access this abstract nowINTRODUCTION
Invasive squamous cell carcinoma (SCC) may present clinically with or without a horn.
OBJECTIVE
To compare invasive SCC with or without horn presentation by anatomic site, tumor diameter, depth, and grade of differentiation.
MATERIALS AND METHODS
The above characteristics of invasive SCC with or without horns were compared using a logistic regression model adjusted for potential confounders.
RESULTS
There were 7.0% horns (n = 116) and 93.0% nonhorns (n = 1,550) in 1,666 cases. The median tumor diameter was 6 mm for horns, and 8 mm for nonhorn cases, p < .001. The median depth of invasion was 0.8 mm for horn cases and 1.3 mm for nonhorns, p < .001. Most cases were well-differentiated SCC for both horns (n = 102, 87.9%) and nonhorns (n = 1,265, 81.6%) p = .07. Horn cases had a borderline significant shift to well differentiation with moderate differentiation in 11.2% of cases (n = 13) and poor differentiation in 0.9% (n = 1).
CONCLUSION
Horns presented on invasive SCC with reduced tumor diameters and reduced invasion depths compared to nonhorns. Horns presenting on invasive SCC were usually well differentiated. However, moderate and even poor differentiation can occur within a horn base.
Click on any of these tags to subscribe to Topic Alerts. Once subscribed, you can get a single, daily email any time PracticeUpdate publishes content on the topics that interest you.
Visit your Preferences and Settings section to Manage All Topic Alerts
Additional Info
Disclosure statements are available on the authors' profiles:
Invasive Squamous Cell Carcinoma: A Comparison of Tumors With or Without Horn Presentation Based on Age, Sex, Anatomic Site, Tumor Diameter, Depth of Invasion, and Grade of Differentiation in 1,666 Cases
Dermatol Surg 2016 May 25;[EPub Ahead of Print], JH Pyne, E Myint, E Barr, SP Clark, R NaFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
The presence of a cutaneous horn is a sign of a well-differentiated tumor, and, to that extent, engenders a better prognosis than random squamous cell carcinomas. It could also be that the presence of a horn calls attention to the lesion, prompting earlier intervention than might otherwise be the case.