Efficacy of mRNA COVID-19 Vaccination During Pregnancy to Prevent COVID-19–Associated Hospitalization in Infants Aged <6 Months
abstract
This abstract is available on the publisher's site.
Access this abstract nowCOVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or who might become pregnant in the future, to protect them from COVID-19.§ Infants are at risk for life-threatening complications from COVID-19, including acute respiratory failure (1). Evidence from other vaccine-preventable diseases suggests that maternal immunization can provide protection to infants, especially during the high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent studies of COVID-19 vaccination during pregnancy suggest the possibility of transplacental transfer of SARS-CoV-2-specific antibodies that might provide protection to infants (3-5); however, no epidemiologic evidence currently exists for the protective benefits of maternal immunization during pregnancy against COVID-19 in infants. The Overcoming COVID-19 network conducted a test-negative, case-control study at 20 pediatric hospitals in 17 states during July 1, 2021-January 17, 2022, to assess effectiveness of maternal completion of a 2-dose primary mRNA COVID-19 vaccination series during pregnancy against COVID-19 hospitalization in infants. Among 379 hospitalized infants aged <6 months (176 with COVID-19 [case-infants] and 203 without COVID-19 [control-infants]), the median age was 2 months, 21% had at least one underlying medical condition, and 22% of case- and control-infants were born premature (<37 weeks gestation). Effectiveness of maternal vaccination during pregnancy against COVID-19 hospitalization in infants aged <6 months was 61% (95% CI = 31%-78%). Completion of a 2-dose mRNA COVID-19 vaccination series during pregnancy might help prevent COVID-19 hospitalization among infants aged <6 months.
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Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022
MMWR Morb. Mortal. Wkly. Rep. 2022 Feb 18;71(7)264-270, NB Halasa, SM Olson, MA Staat, MM Newhams, AM Price, JA Boom, LC Sahni, MA Cameron, PS Pannaraj, KE Bline, SS Bhumbra, TT Bradford, K Chiotos, BM Coates, ML Cullimore, NZ Cvijanovich, HR Flori, SJ Gertz, SM Heidemann, CV Hobbs, JR Hume, K Irby, S Kamidani, M Kong, ER Levy, EH Mack, AB Maddux, KN Michelson, RA Nofziger, JE Schuster, SP Schwartz, L Smallcomb, KM Tarquinio, TC Walker, MS Zinter, SM Gilboa, KN Polen, AP Campbell, AG Randolph, MM PatelFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.