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Published in Cardiology

Expert Opinion / Commentary · March 21, 2016

Vagal Nerve Stimulation for Heart Failure

Written by
Chance M Witt MD
Samuel J Asirvatham MD, FACC, FHRS
Suraj Kapa MD


Additional Info

  1. Premchand RK, Sharma K, Mittal S, et al. Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: Results of the ANTHEM-HF Trial. J Cardiac Fail. 2014;20(11):808-816.
  2. Zannad F, De Ferrari GM, Tuinenburg AE, et al. Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. Eur Heart J. 2015;36(7):425-433.
  3. Kapa S, Venkatachalam KL, Asirvatham SJ. The autonomic nervous system in cardiac electrophysiology: an elegant interaction and emerging concepts. Cardiol Rev. 2010;18(6):275-84.
  4. Kapa S, DeSimone CV, Asirvatham SJ. Innervation of the heart: an invisible grid within a black box. Trends Cardiovasc Med. 2015;26(3):2245-247.
  5. Katritsis DG, Pokushalov E, Romanov A, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2013;62(24):2318-2325.
  6. DeSimone CV, Madhavan M, Venkatachalam KL, et al. Percutaneous autonomic neural modulation: a novel technique to treat cardiac arrhythmia. Cardiovasc Revasc Med. 2013;14(3):144-148.
  7. Schwartz PJ, Motolese M, Pollavini G, et al. Prevention of sudden cardiac death after a first myocardial infarction by pharmacologic or surgical antiadrenergic interventions. J Cardiovasc Electrophysiol. 1992;3(1):2-16.
  8. Collura CA, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm. 2009;6(6):752-759.
  9. Shen MJ, Shinohara T, Park HW, et al. Continuous low-level vagus nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines. Circulation. 2011;123(20):2204-2212.
  10. Libbus I, Nearing BD, Amurthur B, et al. Autonomic Regulation Therapy Suppresses Quantitative T-Wave Alternans and Improves Baroreflex Sensitivity in Heart Failure Patients Enrolled in the ANTHEM-HF Study. Heart Rhythm. 2016;13(3):721-728.
  11. Cygankiewicz I, Zareba W, Vazquez R, et al. Heart rate turbulence predicts all-cause mortality and sudden death in congestive heart failure patients. Heart Rhythm. 2008;5(8):1095-1102.
  12. Sakaki K, Ikeda T, Miwa Y, et al. Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study. Heart Rhythm. 2009;6(3):332-337.

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