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Published in Brain Cancer

Expert Opinion / Cases · February 01, 2022

Treatment of Primary CNS Lymphoma Refractory to High-Dose Methotrexate

Written by
L. Nicolas Gonzalez Castro MD, PhD


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  • alluru raju

    Feb 02, 2022

    As there is progression of the disease  with HD MTX She can be given Radiation along with steroids.

  • Amir Anvari

    Feb 04, 2022

    Unfortiantly the patient has poor prognosis.my recommendation in radiotherapy whole brain 45 to 50 GY in 25 to 30  fraction

  • Serkan Akin

    Feb 08, 2022

    She is too young for RT. Side effects of RT such as dementia will force her. If there is clinical trial, it is suitable for this patient. Drugs such as BTK inhibitors, e.g. ibrutinib has shown promising results. It may be combined with checkpoint inhibitors. Regimen like Nivo-Ibrutinib may be an option. Another promosing results are coming with CAR-T cell therapies. PCNSL are also responsive to these immunotherapies

  • Jul 04, 2022

    Pending Moderator approval.

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