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Feb 02, 2022
As there is progression of the disease with HD MTX She can be given Radiation along with steroids.
Feb 04, 2022
Unfortiantly the patient has poor prognosis.my recommendation in radiotherapy whole brain 45 to 50 GY in 25 to 30 fraction
Feb 08, 2022
She is too young for RT. Side effects of RT such as dementia will force her. If there is clinical trial, it is suitable for this patient. Drugs such as BTK inhibitors, e.g. ibrutinib has shown promising results. It may be combined with checkpoint inhibitors. Regimen like Nivo-Ibrutinib may be an option. Another promosing results are coming with CAR-T cell therapies. PCNSL are also responsive to these immunotherapies
Jul 04, 2022
Pending Moderator approval.
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