To investigate prevalence, course, and predictors of longitudinal decision regret in long-term prostate cancer (PC) survivors treated by radical prostatectomy (RP).
PATIENTS AND METHODS
1003 PC survivors from the multicentre German Familial PC Database completed questionnaires on average seven years after RP in 2007 and at follow-up 13 years later in 2020. Patients completed standardized patient-reported outcome measures on decision regret, decision-making, HRQoL, and psychosocial factors. Hierarchical multivariable logistic regression was used to assess predictors of longitudinal decision regret.
Decision regret increased significantly over time (9.0% after 6.9 years in 2007 and 12% after 19 years in 2020; p=0.009). Favourable localized PC (OR 1.97, 95% CI 1.05-3.68), decision regret in 2007 (OR: 6.38, 95% CI 3.55-11.47), and a higher depression score (OR 1.37 95% CI 1.03-1.83) were associated with decision regret in 2020. Shared decision-making (OR: 0.55, 95% CI 0.33-0.93) was associated with less decision regret.
Findings of the present study underline the perseverance of decision regret in long-term PC survivors and the definitive need for involving patients in the decision-making process to mitigate regret over the long term.