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Traditional Dietary Advice vs a Low FODMAP Diet and Gluten-Free Diet for Non-Constipated IBS
abstract
This abstract is available on the publisher's site.
Access this abstract now Full Text Available for ClinicalKey SubscribersBACKGROUND & AIMS
Various diets are proposed as first-line therapies for non-constipated irritable bowel syndrome (IBS) despite insufficient or low-quality evidence. We performed a randomized trial comparing traditional dietary advice (TDA) against the low FODMAP diet (LFD) and gluten-free diet (GFD).
METHODS
Patients with Rome IV-defined non-constipated IBS were randomized to TDA, LFD, or GFD (the latter allowing for minute gluten cross-contamination). The primary end point was clinical response after 4 weeks of dietary intervention, as defined by ≥50-point reduction in IBS symptom severity score (IBS-SSS). Secondary end points included (1) changes in individual IBS-SSS items within clinical responders, (2) acceptability and food-related quality of life with dietary therapy, (3) changes in nutritional intake, (4) alterations in stool dysbiosis index, and (5) baseline factors associated with clinical response.
RESULTS
The primary end point of ≥50-point reduction in IBS-SSS was met by 42% (n = 14/33) undertaking TDA, 55% (n = 18/33) for LFD, and 58% (n = 19/33) for GFD (P = .43). Responders had similar improvements in IBS-SSS items regardless of their allocated diet. Individuals found TDA cheaper (P < .01), less time-consuming to shop (P < .01), and easier to follow when eating out (P = .03) than the GFD and LFD. TDA was also easier to incorporate into daily life than the LFD (P = .02). Overall reductions in micronutrient and macronutrient intake did not significantly differ across the diets. However, the LFD group had the greatest reduction in total FODMAP content (27.7 g/day before intervention to 7.6 g/day at week 4) compared with the GFD (27.4 g/day to 22.4 g/day) and TDA (24.9 g/day to 15.2 g/day) (P < .01). Alterations in stool dysbiosis index were similar across the diets, with 22%-29% showing reduced dysbiosis, 35%-39% no change, and 35%-40% increased dysbiosis (P = .99). Baseline clinical characteristics and stool dysbiosis index did not predict response to dietary therapy.
CONCLUSIONS
TDA, LFD, and GFD are effective approaches in non-constipated IBS, but TDA is the most patient-friendly in terms of cost and convenience. We recommend TDA as the first-choice dietary therapy in non-constipated IBS, with LFD and GFD reserved according to specific patient preferences and specialist dietetic input.
CLINICALTRIALS
gov: NCT04072991.
Additional Info
Disclosure statements are available on the authors' profiles:
Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet, and the Gluten-Free Diet
Clin. Gastroenterol. Hepatol. 2022 Dec 01;20(12)2876-2887.e15, A Rej, DS Sanders, CC Shaw, R Buckle, N Trott, A Agrawal, I AzizFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
The best diet for non-constipated IBS
In the United Kingdom, the most recommended diet for IBS-diarrhea and IBS-mixed is traditional dietary advice (TDA). These recommendations include eating regularly and avoiding large meals; staying hydrated; limiting the intake of ETOH, caffeine, and fizzy drinks; avoiding fatty, spicey, and processed foods; not eating more than three servings of fruit daily; avoiding gas-producing foods including excess fiber, beans, bread and artificial sweeteners; and lastly, removing any food intolerances.
In North America, The FODMaP diet is the top recommended diet for IBS. It reduces fermentable sugars in the diet. A previous study comparing a low FODMaP diet with a diet similar to the TDA showed that both improved IBS symptoms but the FODMaP diet was associated with a greater improvement.
This study also included a low-gluten diet, maybe in part because it was funded by a gluten-free food company. There were 33 individuals in each group and IBS symptoms were followed using the IBS-SSS tool. A positive response was measured by a >50-point reduction. After 4 weeks, the results showed:
Traditional Dietary Advice 42% (n = 14/33) % that would continue the diet: 70%
Low FODMaP Diet 55% (n = 18/33) % that would continue the diet: 67%
Low Gluten Diet 58% (n = 19/33) % that would continue the diet: 61%
The TDA was the easiest to incorporate into one’s lifestyle.
There is a lot of overlap among these three diets. For example, a gluten-free diet is low in FODMaP sugars (fructans), and the TDA recommends reducing gaseous foods and any intolerant foods (gluten). If we were going to combine the best of all these diets into one recommendation that was relatively easy to incorporate, it might look like the recommendations I have summarized below into a patient handout.
Dietary recommendations for irritable bowel