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Data from patients with cutaneous manifestations of COVID-19 and information on PCR and/or antibody testing were collected from a provider-entered registry. PCR positivity for COVID-19 occurred on a median of 6 days following cutaneous symptom onset; PCR negativity occurred on a median of 14 days later. Antibody testing (IgM or IgG) was positive a median of 30 days after cutaneous symptom onset.
The kinetics of nasopharyngeal shedding of COVID-19 are not well-known for nonrespiratory presentations. In this study, the median number of days until positive antibodies were found fell outside the recommended testing window (14–21 days). More studies are needed clarifying the optimal PCR and antibody testing window in patients with nonrespiratory symptoms due to COVID-19.
– Margaret Hammond, MD
This abstract is available on the publisher's site.
Growing evidence supports a causal relationship between SARS-CoV-2 and cutaneous manifestations1,2 However, interpretation of SARS-CoV-2 PCR/antibody results in dermatology patients with probable COVID-19 infection remains difficult due to lack of data to inform optimal test timing.
Our international registry for cutaneous manifestations of COVID-19 1,3 asked providers to report time between dermatologic symptom onset and positive/negative COVID-19 laboratory results. From 8 April-30 June, 2020, 906 laboratory-confirmed or suspected COVID-19 cases with dermatologic manifestations were reported, 534 of which were chilblains/pernio. Among PCR-tested patients, 57% (n=208) of overall and 15% (n=23) of chilblains/pernio cases were PCR-positive. Antibody positivity was 37% (n=39) overall and 19% (n=15) for chilblains/pernio.