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Expert Opinion / Cases · March 18, 2021

Systemic Treatment for Patient With Progressing mCRPC

Written by
Pedro C. Barata MD


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  • Gregory Lewis

    Mar 19, 2021

    4 - pembrolizumab 
       In prostate cancer, CDK12 mutations occur in 5%−7% of patients with mCRPC, and most are biallelic inactivations.
       CDK12-altered/mutated prostate cancer is an aggressive subtype with poor responses and outcomes to hormonal, taxane, and PARP inhibitor therapies. A proportion of these patients may respond favorably to PD-1 inhibitors, which implicates CDK12 deficiency in immunotherapy sensitivity.

  • Juan Artigas

    Mar 19, 2021

    He should be treated with cabazitaxel and pembrolizumab. CDK12 does not respond to PARP inhibitors.

  • Bahram Mofid

    Mar 23, 2021

    He should be treared with pembrolizumab

  • Charles Maack

    May 07, 2021

    pembrolizumab as explained by Gregory Lewis

  • Noureddine Benjaafar

    Jun 12, 2021

    Pembroluzumab or cabazitaxel

  • silvia scalbi

    May 18, 2022


  • Charles Maack

    May 19, 2022

    Will we ever be provided what subsequent protocol was followed or what the author was aware in advance when we participate in these questions for our opinion?

  • Jun 22, 2024

    Pending Moderator approval.

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