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4 - pembrolizumab
In prostate cancer, CDK12 mutations occur in 5%−7% of patients with mCRPC, and most are biallelic inactivations.
CDK12-altered/mutated prostate cancer is an aggressive subtype with poor responses and outcomes to hormonal, taxane, and PARP inhibitor therapies. A proportion of these patients may respond favorably to PD-1 inhibitors, which implicates CDK12 deficiency in immunotherapy sensitivity.
He should be treated with cabazitaxel and pembrolizumab. CDK12 does not respond to PARP inhibitors.
He should be treared with pembrolizumab
Pending Moderator approval.
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