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Performing ophthalmic surgery safely during the COVID-19 pandemic is important to ophthalmologists, anesthesiologists, nurses, patients and health policy analysts. While ophthalmic procedures themselves are not a major source of transmission,1 the upper respiratory tract may harbor high concentrations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).2 Since there is concern that routine ophthalmic procedures may potentiate the spread of respiratory droplets onto operating room personnel, some centers mandate masks for all operative patients.3 Herein, a series of simulations of a coughing patient during ophthalmic surgery were conducted to identify the potential spread of respiratory droplets and evaluate interventions aimed at mitigating droplet spread from patients to operating room personnel.