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Published in Neurology

Expert Opinion / Commentary · March 17, 2015

Should the Ketogenic Diet be Considered When All Else Fails in Infants and Children With Super Refractory Status Epilepticus?

Written by
Michael Cardamone MD
Preena Uppal MBBS, MD


Additional Info

  1. Shorvon SD, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134(Pt 10):2802-2818.
  2. Freeman JM, Kossoff EH. Ketosis and the ketogenic diet, 2010: advances in treating epilepsy and other disorders. Adv Pediatr. 2010;57(1):315-329.
  3. Nabbout R, Mazzuca M, Hubert P, et al. Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia. 2010;51(10):2033-2037.
  4. Bleck TP. High-dose pentobarbital treatment of refractory status epilepticus: a meta-analysis of published studies. Epilepsia. 1992;33:5.

  5. Dulac O, Takahashi T. Status epilepticus. Handb Clin Neurol. 2013;111:681-689.
  6. Wheless JW. Treatment of refractory convulsive status epilepticus in children: other therapies. Semin Pediatr Neurol. 2010;17(3):190-194.
  7. Cobo N, Sankar R, Murata KK, Sewak SL, Kezele MA, Matsumoto JH. The ketogenic diet as broad-spectrum treatment for super-refractory staus epilepticus: challenges in implementation in the pediatric and neonatal intensive care units. J Child Neurol. 2015;30(2):259-256.

  8. Selter JH, Turner Z, Doerrer SC, Kossoff EH. Dietary and medication adjustments to improve seizure control in patients treated with the ketogenic diet. J Child Neurol. 2015;30(1):53-57.

Further Reading