The novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) threatens human health and the mortality rate is higher in patients who develop myocardial damage. However, the possible risk factors for myocardial damage in patients with coronavirus disease 2019 (COVID‐19) are not fully known.
Methods and Results
Critical type patients were selected randomly from 204 confirmed COVID‐19 cases occurring in Renmin Hospital of Wuhan University, from February 1, 2020 to February 24, 2020. Univariate analyses were used to compare the two groups: the myocardial damage group and the non‐myocardial damage group. A total of 82 critical patients with COVID‐19 were recruited: 34 with myocardial damage and 48 without myocardial damage. Thirty patients died in the myocardial damage group, and 20 died in the non‐myocardial damage group. In univariate analysis, the proportion of elderly patients (>70 y: 70.59% vs 37.50%; P=0.003) and patients with cardiovascular disease (41.18% vs 12.50%; P=0.003) was higher among myocardial damage patients than among non‐myocardial damage patients. Multivariate analysis showed that age>70 years old (HR 2.44, 95% CI 1.01‐5.40), C‐reactive protein greater than 100 mg/L (HR 1.92, 95% CI 0.94‐3.92), lactate dehydrogenase greater than 300 U/L (HR 2.67, 95% CI 1.03‐6.90), and lactic acid greater than 3 mmol/L (HR 3.25, 95% CI 1.57‐6.75) were independent risk factors for myocardial damage in patients with COVID‐19.
Old age (>70 years), C‐reactive protein greater than 100 mg/L, lactate dehydrogenase greater than 300 U/L and lactic acid greater than 3 mmol/L are high‐risk factors related to myocardial damage in critical patients with COVID‐19.