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This literature review of acne in adults details new evidence on the pathophysiology of acne development and newly approved targeted therapeutics. The relationship between gastrointestinal health and skin microbiota and the impact of antibiotics on homeostasis are explored. Furthermore, newly approved treatment options and the role of emerging agents in the development of acne are briefly reviewed.
Clinicians should be aware of the new research regarding acne pathogenesis and the emerging therapeutic options to treat this condition.
Acne affects more than 640 million people worldwide, including about 85% of adolescents. This inflammatory dermatosis affects the entire population, from teenagers to adults, which reinforces the need to investigate it. Furthermore, in adults, acne has serious consequences, including a psychological impact, low self-esteem, social isolation, and depression. Over the last years, the understanding of acne pathophysiology has improved, mainly thanks to the identification of the pivotal role of the microbiota. The aim of this review was to screen the most recent scientific literature on adult acne and the newly tested treatments. Clinically, therapeutic innovations for the treatment of acne have been recently developed, including pre/probiotics, new molecules, and innovative formulations associated, however, with fewer side effects. Moreover, clinical trials are underway to use off-label molecules that seem to be proving their value in the fight against adult acne.