Proximal Esophageal Impedance Baseline for Predicting Response to PPIs in Patients With Chronic Cough
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND
Chronic cough significantly impairs the quality of life. Although various studies focused on MNBI as assessed in the distal esophagus, scarce data are available on the clinical value of proximal measurements.
AIM
To investigate the role of proximal MNBI in the workup of patients with chronic cough and its ability to predict PPI response.
METHODS
Demographic, clinical, endoscopy findings, impedance-pH and HRM tracings from consecutive cough patients were evaluated. MNBI was calculated at proximal and distal esophagus.
RESULTS
One hundred and sixty four patients were included. In addition to traditional variables, when considering also the PSPW index or MNBI at 3 cm or 15 cm, the proportion of patients with pathological impedance-pH monitoring significantly increased. 70/164 patients were responders, while 94 (57.3%) were non-responder to double PPI dose (p < 0.05). Patients with pathologic MNBI at 3 cm and/or 15 cm as well as those with pathologic PSPW index were characterized by a significantly higher proportion of responders than that observed among patients with normal impedance-pH variables (p < 0.001). The proportion of responders with pathological MNBI at 15 cm was significantly higher than the proportion of responders with pathological MNBI at 3 cm (82.8% vs. 64.3%, p < 0.05). At multivariable model, pathological MNBI at both 3 cm and 15 cm as well as PSPW index were associated with PPI responsiveness. The strongest association with PPI response was observed for MNBI at 15 cm.
CONCLUSIONS
The assessment of MNBI at proximal esophagus increases the diagnostic yield of impedance-pH monitoring and may represent a useful predictor of PPI responsiveness in the cumbersome clinical setting of suspected reflux-related cough.
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Additional Info
Proximal esophageal impedance baseline increases the yield of impedance-pH and is associated with response to PPIs in chronic cough patients
Neurogastroenterol. Motil. 2024 Feb 29;[EPub Ahead of Print], M Ribolsi, N De Bortoli, M Frazzoni, L Marchetti, E Savarino, M CicalaFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.