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This study, consisting of 50 patients, aimed to evaluate the prevention of post-extraction bacteraemia following single-dose antibiotic prophylaxis prior to extraction. The patients were treated as follows: 76% received prophylactic oral amoxicillin or intravenous ampicillin (AMX/AMP; 2 g), 12% received clindamycin (CLI; 600 mg), and 12% received no prophylaxis (NO AP). All baseline blood cultures were negative. The prevalence of bacteraemia was significantly higher in the CLI and NO AP groups compared with the AMX/AMP group 5 minutes after the first tooth extraction. At 20 minutes after the last extraction, positive blood cultures were reported for CLI and NO AP groups.
The authors concluded that AMX/AMP proved its efficacy in reducing both the prevalence and duration of bacteraemia, whereas CLI was not effective.
– Luiz Meirelles, DDS, MS, PhD
This abstract is available on the publisher's site.
To evaluate the efficacy of single-dose antibiotic prophylaxis (AP) in the prevention of bacteraemia following tooth extractions at our clinic.
MATERIAL AND METHODS
Fifty patients undergoing tooth extractions were enrolled. The need of AP was determined according to the health status and possible allergies of the patients. Blood culture samples were collected at baseline, 5 min after the first tooth extraction and 20 min after the last extraction.
The majority (76%) received prophylactic oral amoxicillin or intravenous ampicillin (AMX/AMP) (2 g), 12% received clindamycin (CLI) (600 mg) and 12% received no prophylaxis (NO AP). All baseline blood cultures were reported negative. The prevalence of bacteraemia was significantly higher in the CLI and NO AP groups compared to the AMX/AMP group 5 min after the first tooth extraction (p < .0001 and p = .015, respectively). Twenty minutes after the last extraction positive blood cultures were reported only for CLI (p = .0015) and NO AP groups. There was no significant difference in the prevalence of positive blood cultures between CLI and NO AP groups.
Appropriately administered AMX/AMP proved its efficacy in reducing both the prevalence and duration of bacteraemia following tooth extractions whereas CLI was not effective in preventing bacteraemia following tooth extractions.