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Published in Renal Cell Carcinoma

Expert Opinion / Cases · December 08, 2015

Progression on Multiple Lines of Therapy

Written by
Andrew Fintel DO


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  • George Yaghmour

    Immunotherapy is good choice. However, considering the Good PS and CCRCC pathology would also consider Cabozantinib per Toni choueiri et al NEJM article.

  • George Yaghmour

    Given the good PS and the extent of disease. Considering SBRT and debunking recurrent disease then consider further treatment. Also the updated results from expanded cohorts in CheckMate 016 confirmed initial safety findings and promising anti tumor activity for nivolumab + ipilimumab in patients with metastatic renal cell carcinoma. Overall survival for the combination in metastatic renal cell carcinoma is encouraging.

  • Angel Rodriguez

    Another option is retreatment with the best tki used previously

  • Oct 31, 2020

    Pending Moderator approval.

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