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Using clinical examination and imaging data in a hospital setting, this study assessed the prevalence of acute periapical abscesses (PAs) in patients using selective serotonin reuptake inhibitors (SSRIs). Patients with a history of SSRI use were significantly more likely to be diagnosed with an acute PA than those without a history of SSRI use (OR, 2.18). Female patients were significantly more likely to be affected than male patients by twofold, and Whites were significantly more likely to be affected than African Americans by 2.4-fold.
Millions of individuals take SSRIs for the treatment of anxiety and depression. Although further studies are warranted to assess the exact cause and effect between the use of SSRIs and the prevalence of acute PAs, dentists should be aware of their possible association.
Depression and anxiety are severe health problems affecting millions of individuals worldwide. Consequently, the use of antidepressants has constantly been on a rise. Selective serotonin reuptake inhibitors (SSRIs) antidepressant are now commonly used due to fewer side effects as compared to other types of antidepressants. The aim of this study was to assess the prevalence of periapical abscesses (PAs)in patients using SSRIs.
METHODS AND RESULTS
Integrated data of hospital patients was used. Data from the corresponding diagnosis codes for SSRIs and acute PAs was retrieved by searching the appropriate query in the database. The different diagnoses were coded using the international coding systems ICD 10. Diagnosis was made by calibrated dentists in a hospital setting based on clinical examination and imaging data. The odds ratio (OR) for the prevalence of acute PAs and its association with the use of SSRIs were calculated and analyzed statistically. It was found that the prevalence of acute PAs was significantly higher in patients using SSRIs as compared to the other hospital patient population. The OR was 2.8 and the difference between patients using SSRIs and patients who do not was statistically significant (p < .0001).
Under the conditions of this study, it appears that the prevalence of acute PAs is higher in patients using SSRIs.