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Outcomes of Treatment With Oral Isotretinoin Plus Desloratadine vs Oral Isotretinoin Alone in Patients With Moderate to Severe Acne
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND
Our aim was to measure the effectiveness of oral isotretinoin with desloratadine compared with oral isotretinoin alone in treating moderate to severe acne at a tertiary care teaching hospital in North India. In this study, 90 patients with moderate to severe acne were enrolled to participate based on their fulfilling the inclusion criteria.
METHODS
A randomized, assessor-blinded, parallel-arm study was conducted. Randomization was done using computer-generated tables to allocate treatments in a 1:1 ratio. A low-dose oral isotretinoin at a dose of 0.3 mg/kg/day with tab desloratadine at 5 mg/day was applied to the study group and compared against the same patients going without the dosage when controls were conducted. Follow-up was at 4, 8, and 12 weeks.
RESULTS
The primary outcome was an improved global acne grading system (GAGS) score and decreased acne lesion count.
SECONDARY OUTCOME
patient satisfaction with treatment. The 90 participants were randomized and 15 participants dropped out of the study, leaving 75 participants for intention to treat analysis (n = 41, n = 30). At week 12, the GAGS score and acne lesion count between the study and control groups were comparable (P > 0.05). Pruritus reported was 9.76% in the study versus 33.33% in the control group (P = 0.018). Also, 53.66% of participants reported "excellent" treatment satisfaction in the study group versus 36.67% in the control group.
CONCLUSIONS
The addition of desloratadine to an isotretinoin regimen has a role in reducing disease and therapy-related pruritus in acne and leads to improved patient satisfaction.
Additional Info
Oral isotretinoin with desloratadine compared with oral isotretinoin alone in the treatment of moderate to severe acne: a randomized, assessor-blinded study
Int. J. Dermatol 2024 Mar 28;[EPub Ahead of Print], N Hazarika, P Yadav, M Bagri, D Chandrasekaran, R BhatiaFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.