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Using data from the Clinical Characterisation Protocol UK cohort, these study authors investigated associations between obesity and adverse COVID-19 outcomes in different ethnic groups. Adverse outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality; outcomes were adjusted for age, sex, and chronic comorbidity. Ethnicity was defined as white, South Asian, and black and other minority ethnic groups. Obesity was associated with all adverse COVID-19 outcomes in all ethnic groups, but associations were strongest for black ethnicity. Compared with white ethnicity without obesity, black ethnicity with obesity had greater odds of admission to critical care (OR, 3.9), mechanical ventilation (OR, 5.0), and mortality (OR, 1.9).
Patients with obesity admitted to hospital for COVID-19 are at higher risk of adverse outcomes, particularly if they are black.
To investigate the association of obesity with in-hospital COVID-19 outcomes in different ethnic groups.
Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from 6th February to 12th October 2020. Ethnicity was classified as: white, South Asian, black and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation and in-hospital mortality, adjusted for age, sex and chronic diseases.
54,254 (age = 76 years; 45.0% women) white, 3,728 (57 years; 41.1%) South Asian, 2,523 (58 years; 44.9%) black and 5,427 (61 years; 40.8%) other ethnicities were included. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the OR for admission to critical care, mechanical ventilation and mortality in black ethnicities with obesity were 3.91 (3.13, 4.88), 5.03 (3.94, 6.63), 1.93 (1.49, 2.51) respectively, compared to white ethnicities without obesity.
Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in black ethnicities.
Obesity, Ethnicity and Risk of Critical Care, Mechanical Ventilation and Mortality in Patients Admitted to Hospital With COVID-19: Analysis of the ISARIC CCP-UK Cohort
Obesity 2021 Mar 23;[EPub Ahead of Print], T Yates, F Zaccardi, N Islam, C Razieh, CL Gillies, CA Lawson, Y Chudasama, A Rowlands, MJ Davies, AB Docherty, PJ Openshaw, JK Baillie, MG Semple, ISARIC4C investigators, K Khunti