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Published in Renal Cell Carcinoma

Expert Opinion / Cases · March 01, 2016

New Abdominal Mets in RCC Patient: What is the 2nd Line Treatment?

Written by
Heather R Greene MSN, FNP, AOCNP

 

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Heather Greene MSN, FNP, AOCNP

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  • Bradley Somer MD

    Bradley G. Somer MD

    Feb 03, 2016

    He has had approximately 17 month PFS on Votrient for papillary RCC. He seemed to have had a good and durable response. Upon progression, there is no clear standard. NCCN lists no clear consensus second line standard therapy for non-clear cell. Checkmate-025, where nivolumab is expected to do better than on mTOR inhibitors:  http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510665  included only clear cell carcinoma. He would be a candidate for the checkmate-374 study which is a ph3/4 of nivolumab and includes potentially non-clear cell histology. Other trials which he may be eligible for is an AR positive basket trial. There is some pre-clinical data on AR in kidney cancer and perhaps SARM could be a strategy that could be investigated in AR + patients on clinical trials.  

  • Angel Rodriguez

    May 05, 2016

    Without evindence, a option can be axitinib due to good response in first line with one tki

  • Amanullah Memon

    May 13, 2016

    in absence of clear consensus on standard therapy for papillary RCC 17 month PFS makes Votrient a credible choice.

  • Apr 19, 2024

    Pending Moderator approval.
    Delete

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