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Among adults aged ≥75 years, there was no increase in the short-term risk of acute myocardial infarction, stroke, or pulmonary embolism in the 14 days following either dose of the Pfizer-BioNTech SARS-CoV-2 vaccine.
Vaccination appears safe in older adults, but further study is warranted to confirm these findings.
The BNT162b2 mRNA vaccine (Pfizer-BioNTech) was the first SARS-CoV-2 vaccine authorized and most widely used in older persons in France. Although no increases in cardiovascular events were reported in the phase 3 trials,1 questions emerged once the vaccine was used on a large scale because older people were underrepresented in the trials. We evaluated the short-term risk of severe cardiovascular events among French people aged 75 years or older after the administration of the BNT162b2 mRNA vaccine.