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The authors conducted a retrospective cohort study at Kaiser Permanente Southern California to compare the rate of hospitalization and risk of death due to COVID-19 between non-MS patients and MS patients treated with rituximab. A higher rate of hospitalization, but not mortality, was observed for the patients with MS (33.3% and 0%, respectively) compared with the non-MS population (5.8% and 1.4%, respectively).
Independent predictors of COVID-19 severity were time in months since last treatment (aOR, 0.32; P = .0033) and receiving higher (1000 mg) rather than lower doses of rituximab at the last infusion (aOR, 6.28; P = .0173).