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The authors review the historical outbreaks, modes of transmission, and clinical manifestations of monkeypox as well as the diagnostic methods and treatment options for monkeypox. The current outbreak may have a less severe prodrome with characteristic vesicular lesions potentially limited to the genital region.
Dermatologists will play an integral role in recognizing cases of monkeypox and should include monkeypox in the differential diagnosis for vesiculopustular eruptions and genital ulcers. Prompt diagnosis and containment of monkeypox are crucial to preventing the spread of the disease.
The current monkeypox outbreak reawakens the concern that poxviridae have high potential of zoonotic spillover and for causing pandemic.1 Much fieldwork and research has been done by healthcare and public health workers in Africa during previous human outbreaks, and their knowledge should inform our global response to the current outbreak. However, unusual clinical presentations now have potential implications in recognizing disease. Infections from poxviridae such as monkeypox have common cutaneous signs that occur early, may be related to periods of transmissibility, and can leave scarring. Therefore, dermatologists will play a key role in recognizing and diagnosing infections, and in educating and preparing front-line healthcare workers for early detection of new cases and clusters of monkeypox.