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Microvascular Injury in the Brains of Patients With COVID-19
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The authors present results of postmortem high-resolution brain magnetic resonance imaging and histopathological examination of patients who died from COVID-19. Abnormalities included punctate hyperintensities representing microvascular injury and fibrinogen leakage. Areas of linear hypointensity were interpreted as microhemorrhages. There was perivascular inflammation but no vascular occlusion. SARS-CoV-2 virus was not detected by polymerase chain reaction.
- There was histopathological evidence of multifocal microvascular injury in the brain and olfactory bulbs of patients who died from COVID-19, but there was limited corresponding clinical information.
abstract
This abstract is available on the publisher's site.
Access this abstract nowWe conducted postmortem highresolution magnetic resonance imaging (magnetic resonance microscopy) of the brains of patients with coronavirus disease 2019 (Covid-19) (median age, 50 years) and histopathological examination that focused on microvascular changes in the olfactory bulb and brain stem.
Additional Info
Microvascular Injury in the Brains of Patients With Covid-19
N. Engl. J. Med 2020 Dec 30;[EPub Ahead of Print], MH Lee, DP Perl, G Nair, W Li, D Maric, H Murray, SJ Dodd, AP Koretsky, JA Watts, V Cheung, E Masliah, I Horkayne-Szakaly, R Jones, MN Stram, J Moncur, M Hefti, RD Folkerth, A NathFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.