We have detected that you are using an Ad Blocker. PracticeUpdate is free to end users but we rely on advertising to fund our site. Please consider supporting PracticeUpdate by whitelisting us in your ad blocker.
We have sent a message to the email address you have provided, . If this email is not correct, please update your settings with your correct address.
The email address you provided during registration, , does not appear to be valid. Please update your settings with a valid address before to continue using PracticeUpdate.
Welcome to PracticeUpdate! We hope you are enjoying access to a selection of our top-read and most recent articles. Please register today for a free account and gain full access to all of our expert-selected content.
You can find your saved items on your dashboard, in the "saved" tab.
You've recommended your first item
Your recommendations help us improve our content suggestions for you and other PracticeUpdate members.
You've subscribed to your first topic alert
What does that mean?
Each day, we'll check to see if new items have been published to the topics you're subscribed to, and we'll send you one email with all of the new items from that day.
We'll keep all topic alert notifications available on your dashboard for 30 days, to make sure you don't miss anything.
Lastly, whenever you have unread items in the topics you've subscribed to, the "Alerts" icon will light up in the main menu. Just click on the bell to see your five most-recent, unread notifications.
The authors present results of postmortem high-resolution brain magnetic resonance imaging and histopathological examination of patients who died from COVID-19. Abnormalities included punctate hyperintensities representing microvascular injury and fibrinogen leakage. Areas of linear hypointensity were interpreted as microhemorrhages. There was perivascular inflammation but no vascular occlusion. SARS-CoV-2 virus was not detected by polymerase chain reaction.
There was histopathological evidence of multifocal microvascular injury in the brain and olfactory bulbs of patients who died from COVID-19, but there was limited corresponding clinical information.
– Derrick Tao, MD
This abstract is available on the publisher's site.
We conducted postmortem highresolution magnetic resonance imaging (magnetic resonance microscopy) of the brains of patients with coronavirus disease 2019 (Covid-19) (median age, 50 years) and histopathological examination that focused on microvascular changes in the olfactory bulb and brain stem.
Microvascular Injury in the Brains of Patients With Covid-19
N. Engl. J. Med 2020 Dec 30;[EPub Ahead of Print], MH Lee, DP Perl, G Nair, W Li, D Maric, H Murray, SJ Dodd, AP Koretsky, JA Watts, V Cheung, E Masliah, I Horkayne-Szakaly, R Jones, MN Stram, J Moncur, M Hefti, RD Folkerth, A Nath