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Expert Opinion / Cases · August 23, 2023

Metastatic HR+/HER2− Breast Cancer With Co-Existing ESR1 and PIK3CA Mutation

Written by
Naomi G. Dempsey MD


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  • nguyen nguyen

    Aug 24, 2023

    Choose between these two combinations
    Denosumab, Everolimus, Fulvestrant, T-DxD
    Denosumab, Everolimus, Fulvestrant, Apelisib

  • Comment deleted by Moderator.

    Aug 25, 2023

    fulvestrant +alpelisib

  • Susan Sadighi

    Aug 25, 2023

    Denosumab, Fulvestrant, Apelisib

  • Milka Gonzalez

    Aug 25, 2023

    I choose Alpelisib + Fulvestrant +/- Elacestrant and Denosumab

  • nagib khoury

    Aug 26, 2023

    fulvestrtant , apelisib, denosumab,thus targeting both mutations in esr1 andpi3k and bone health

  • Silvia Falcon

    Aug 28, 2023

    Alpelisib + Fulvestrant + Denosumab

  • pramod kumar julka

    Aug 28, 2023

    Alpelisib fulvestrant denosumab 


    Sep 09, 2023


  • Mar 02, 2024

    Pending Moderator approval.

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