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Expert Opinion / Cases · August 18, 2021

Met recurrence breast cancer to liver with lose of her2 in liver bx

Dr.kawyba A.A.A

 

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  • luis betancourt

    Treatment with TE+Ciclins Inhibitors before SBRT ?


  • nagib khoury

    ET + ABEMA ; better outcomes in liver metastasis and endocrine resistance vs other cdk4-6 inhibitors


  • Lee Schwartzberg

    Conversion to HER2- is not too common but not rare. I have seen heterogenity in different metastatic lesions which means you may need to continue to biopsy new areas of disease. I don't typically treat 2 liver lesions with SBRT but toxicity is low and is reasonable if small lesions. I would continue OFS and switch to Fulvestrant and a CDK 4/6 inhibitor now. May get prolonged disease control. If recurs, definitely biopsy for standard biomarkers and NGS.


  • Sep 27, 2021

    Pending Moderator approval.
    Delete

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