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emine sevil bavbek
Metastatectomy if feasible. Anti VEGF TKI if complete surgery not possible
Giuseppe Di Lucca
1. Surgery and/or SBRT 2. Cabozantinib
Consider local ablative therapy first (metastasectomy or SBRT). If it is not feasible, I would do a biopsy and test the sample for PD-1 and cMET. Then, based on the result, you can choose sunitinib, cabozantinib, or pembrolizumab. And I would also review the circumstances of everolimus toxicity, focusing on dose reductions and supporting measures.
Pending Moderator approval.
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