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This review highlights the current and future side-effect profiles of SARS-CoV-2 vaccines. The authors assert that in the coming months at least five new vaccines will enter the US market, with more in development.
The authors state that monitoring adverse events will be crucial for all current and future COVID-19 vaccines. They make it clear that several questions remain regarding the safety and efficacy of the vaccines in the population.
This abstract is available on the publisher's site.
To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with no serious concerns identified in the ongoing phase 3 clinical trials. Minor local side effects such as pain, redness, and swelling have been observed more frequently with the vaccines than with placebo. Systemic symptoms such as fever, fatigue, headache, and muscle and joint pain have also been somewhat more common with the vaccines than with placebo, and most have occurred during the first 24 to 48 hours after vaccination.1 In the phase 1–3 clinical trials of the Pfizer–BioNTech and Moderna mRNA vaccines, potential participants with a history of an allergic reaction to any component of the vaccine were excluded. The Pfizer–BioNTech studies also excluded participants with a history of severe allergy associated with any vaccine (see the protocols of the two trials, available with the full text of the articles at NEJM.org, for full exclusion criteria). Hypersensitivity adverse events were equally represented in the placebo (normal saline) and vaccine groups in both trials.