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Metastatic Breast Cancer
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CARLOS MONTENEGRO
May 26, 2017
Radiation for chest wall and tamoxifen for 10 years (she can switch on the way)
HAMDI Djelloul
May 26, 2017
Chest radiation , then tamoxifen for 5 years.
Andrea de Matteis
May 28, 2017
No Radiotherapy. If the patient is premenopausal Tamoxifen. After 5 years if postmenopausal Letrozole x 5 years.
Waseem Abbas
Jun 05, 2017
Young patient with a pT3 tumor definitely chemotherapy followed by radiation and ovarian ablation plus Letrazole. If she is not willing then only we can avoid chemotherapy.
CARLOS MONTENEGRO
Jun 19, 2017
Since she has done Oncotype with a low risk result we could avoid CHEMO
Bharat Bhosale
Jul 25, 2017
No chemo
Grade 2
Ki 67 15 %
Strong ER PR positive
Low RS
I would treat with radiation and 5 to 10 years of tamoxifen
ibra algo
Jul 26, 2017
Young age ( 43-ys ) + T3 > 5 cm = yes for Radiation therapy. ONCdx < 11 , (TAILORx). limited for Tumor =<5 cm. this patient > 5 cm . So need to have adjuvant chemotherapy but without anthracycline, since she is LN -VE ER PR +ve (SEE Blum 2017 JCO The ABC TRIALS Anthracyclines in Early Breast Cancer)
Kavi Capildeo
Jul 26, 2017
Agree with above commenters that chemotherapy would not be indicated in this patient with Stage IIB node negative, ER and PR positive breast cancer with a low Oncotype.
Multiple valid options for endocrine therapy including initial Tamoxifen with possible crossover to Letrozole if postmenopausal at 5 yrs as per MA-17, vs. exemestane + ovarian suppression as per SOFT/TEXT.
Postmastectomy RT to chest wall is indicated in view of T3 tumor.
Juan Rodriguez Agostini
Jul 27, 2017
1.- Postmastectomy radiation therapy by tumor size
2.- Only adjuvant hormone therapy + ovarian supression
ANTHONY PAIS
Aug 09, 2017
43 years premenopausal women, ER positive, low KI67. Risk score is low. Nodes negative. Mastectomy done. Would advise only Tamoxifen +/- oophorectomy after discussing with the patient.
thomas tucker
Aug 09, 2017
XRT plus tamoxifen
Waseem Abbas
Aug 10, 2017
Do we have a randomized data .???Chemotherapy vs no chemotherapy in early breast cancer. Oncotype DS is the retrospective data . And other scores have no comparative arm as chemotherapy,Evidence based medicine.....
Shahid Gilani
Aug 14, 2017
Post mastectomy Radiation therapy to chest wall. Ovarian suppression with endocrine treatment for 10 years (AI for 5 years +Tamoxifin for 5 years).
Apr 24, 2024
Pending Moderator approval.
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Sameer
Nasir
MD
CARLOS MONTENEGRO
May 26, 2017
HAMDI Djelloul
May 26, 2017
Andrea de Matteis
May 28, 2017
Waseem Abbas
Jun 05, 2017
CARLOS MONTENEGRO
Jun 19, 2017
Bharat Bhosale
Jul 25, 2017
ibra algo
Jul 26, 2017
Kavi Capildeo
Jul 26, 2017
Juan Rodriguez Agostini
Jul 27, 2017
ANTHONY PAIS
Aug 09, 2017
thomas tucker
Aug 09, 2017
Waseem Abbas
Aug 10, 2017
Shahid Gilani
Aug 14, 2017
Apr 24, 2024
Pending Moderator approval.