Loss of MAT2A Compromises Methionine Metabolism and Represents a Vulnerability in H3K27M Mutant Glioma
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Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome
Nat Cancer 2022 Apr 14;[EPub Ahead of Print], BJ Golbourn, ME Halbert, K Halligan, S Varadharajan, B Krug, NE Mbah, N Kabir, AJ Stanton, AL Locke, SM Casillo, Y Zhao, LM Sanders, A Cheney, SJ Mullett, A Chen, M Wassell, A Andren, J Perez, EP Jane, DRD Premkumar, RF Koncar, S Mirhadi, LH McCarl, YF Chang, YL Wu, TA Gatesman, AF Cruz, M Zapotocky, B Hu, G Kohanbash, X Wang, A Vartanian, MF Moran, F Lieberman, NM Amankulor, SG Wendell, OM Vaske, A Panigrahy, J Felker, KC Bertrand, CL Kleinman, JN Rich, RM Friedlander, A Broniscer, C Lyssiotis, N Jabado, IF Pollack, SC Mack, S AgnihotriFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.