We have detected that you are using an Ad Blocker.
PracticeUpdate is free to end users but we rely on advertising to fund our site. Please consider supporting PracticeUpdate by whitelisting us in your ad blocker.
We have sent a message to the email address you have provided, . If this email is not correct, please update your settings with your correct address.
The email address you provided during registration, , does not appear to be valid. Please update your settings with a valid address before to continue using PracticeUpdate.
Please provide your AHPRA Number to ensure that you are given the correct level of access to our site.

Expert Opinion / Cases · November 19, 2018

Locally Advanced Hormone Receptor Positive Breast Cancer With Multiple Axillary LN Involvement

Written by
Sameer Nasir MD


Discuss This item Follow

No comments yet, be the first to start the discussion!

  • heba  abusin

    Before decision regarding SLND, what is the metastatic work up and KI67, chronic diseases and PS ?

  • N Cul

    Not necessary,as cancer may be in lungs or viseral. CT or MRI more useful.

  • surapong  supaporn

    Adjuvant aromatase inhibitor if luminalA..tamoxifen is contraindicated 21 recurrent score might be beneficial for decision making about chemo therapy 69 years old may not need alnd but radiation therapy to whole breast and regional nodes Alnd is still an option


    I would start hormone treatment with aromatase inhibitor identifying a measurable lesion to evaluate response. After 90 days of medication and attending especially the evolution of his thromboembolic disease, I would think about the locoregional actinic treatment if I have response. I do not see any usefulness of the ALND.

  • zjc0305@live.cn zjc0305@live.cn

    Was it enough to have targeted axillary lymph node dissection only?

  • Jayaprakash Madhavan

    She has ER +ve HER2 _ve T2 N1 disease.Being a luminal A type ALD may be avoided. She needs adj AI.she may be candidate for adjuvant radiation as 3 LN are + VE ONE with ene


    Given that a metastatic lymph node was proven positive upfront she would not qualify por Z0011 or Amaros trials. I think she had an indication por lumpectomy + lymph node dissection or to enrole in a neoadjuvant primary systemic therapy trial like the Alliance

  • Samaneh Sarbaz

    First of all,PS,metastatic work up and ki67 are necessary

  • Dec 04, 2020

    Pending Moderator approval.

Further Reading