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Neurologic manifestations of COVID-19 are well-recognized. The authors present evidence from preclinical research exploring the biologic pathways by which SARS-CoV-2 infection could result in these manifestations. They summarize literature on the epidemiologic data and neurologic features of COVID-19 and then discuss the neuroinvasivity of SARS-CoV-2, including the route and neuropathology of the virus, drawing support from neuropathologic studies as well as neuroimaging data.
Although much of this information is known, this is a valuable review summarizing the neurologic manifestations of COVID-19, raising awareness of how various neurologic symptoms may differ in pathways and mechanisms of pathology.
– Omar Iqbal Khan, MD
This abstract is available on the publisher's site.
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In particular, virus-related neurological manifestations are being reported more and more frequently in the scientific literature. In this article, we review the literature on the association between COVID-19 and neurological manifestations, present evidence from preclinical research suggesting that SARS-CoV-2 could be responsible for many of these manifestations, and summarize the biological pathways that could underlie each neurological symptom. Understanding the mechanisms that lead to neurological manifestations in patients with COVID-19 and how these manifestations correlate with clinical outcomes will be instrumental in guiding the optimal use of targeted therapeutic strategies.