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Kappa Index for MS Diagnosis: An Accurate Biomarker of Intrathecal Synthesis
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND
Cerebrospinal fluid (CSF) kappa-free light chains (KFLC) are becoming a diagnostic biomarker for multiple sclerosis (MS).
OBJECTIVES
We aimed to compare the diagnostic performance of intrathecal synthesis biomarkers to that of oligoclonal bands (OB) in diagnosing MS, radiological and clinical isolated syndromes (RIS-CIS) on a large cohort of patients collected over 10 years.
METHODS
We collected 1124 patients (58% females) in 10 years who underwent CSF analysis for intrathecal synthesis in the diagnostic work-up, and they were classified according to their diagnosis as 417 MS, 287 with other neurological inflammatory disorders (including 76 RIS-CIS), and 420 non-inflammatory diseases (excluding lymphoproliferative and infective diagnosis).
RESULTS
MS patients significantly differ from all other groups (including if considering the RIS-CIS cohort) for CSF KFLC, KFLC intrathecal fraction (IF), Kappa index, and OB. Evaluating the diagnostic performance, the Kappa index cut-off was 6.4 for diagnosing MS and 5.7 for predicting OB. A diagnostic algorithm could avoid IEF if the Kappa index is higher than 20.
CONCLUSIONS
The KFLC index confirmed its accuracy for MS diagnosis in this large Italian cohort, adding information also in the RIS-CIS population.
Additional Info
Disclosure statements are available on the authors' profiles:
Kappa index for multiple sclerosis diagnosis: an accurate biomarker of intrathecal synthesis
J Neurol 2024 Dec 12;272(1)30, D Vecchio, C Puricelli, E Virgilio, F Passarelli, S Guida, P Naldi, I Crespi, U Dianzani, C ComiFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.