Welcome to PracticeUpdate! We hope you are enjoying access to a selection of our top-read and most recent articles. Please register today for a free account and gain full access to all of our expert-selected content.
Already Have An Account? Log in Now
Intake of Antidepressants Increases the Risk of Dental Implant Failure
TAKE-HOME MESSAGE
- This systematic review and meta-analysis looked into the effect of antidepressant intake on dental implant failure at both implant and patient levels. Based on the data from 11 included clinical studies, the meta-analysis revealed a risk ratio of 2.44 and 2.44 for implant failure at the patient and implant levels, respectively. A higher risk of implant failure was noted in patients on selective serotonin reuptake inhibitors (SSRIs) or SSRIs with other types of antidepressants than in those who were not on antidepressants. Limited evidence points to the negative influence of intake of specific medications such as sertraline on dental implant failure more so than others.
- When considering dental implant therapy, clinicians should be aware of the adverse influence of antidepressants such as SSRIs on dental implant health and plan accordingly.
abstract
This abstract is available on the publisher's site.
Access this abstract nowPURPOSE
To analyze the risk of dental implant failure for patients with a history of antidepressant use through a systematic review and meta-analysis.
MATERIALS AND METHODS
An electronic search was performed up to June 2023 in three databases including PubMed/MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials; data on the comparison of implant failure rate for patients with and without the use of antidepressants were included. Meta-analyses for the risk ratio of implant failure rate at patient level and implant level were performed.
RESULTS
Overall, 11 clinical studies were selected for inclusion in this review. The meta-analyses showed a risk ratio of 2.44 (95% CI = 1.75 to 3.39; P < .0001) and 2.44 (95% CI = 1.73 to 3.46; P < .0001) for the implant failure at patient level and implant level, respectively. The comparisons presented a low heterogeneity for the patient-level analysis and a moderate heterogeneity for the implant-level analysis among the pooled studies. Subgroup analyses also revealed that patients who received only selective serotonin reuptake inhibitors (SSRIs) or SSRIs with other types of antidepressants had a higher risk of implant failure than those who were not on any antidepressants.
CONCLUSIONS
The current review demonstrates that the use of antidepressants such as SSRIs may increase the risk of dental implant failure at both patient level and implant level. Although limited evidence suggests that a certain type of SSRI (sertraline) may have more influence on implant failure than other SSRIs, future studies are needed to confirm this finding.
Additional Info
Disclosure statements are available on the authors' profiles:
The Effect of Antidepressants on Dental Implant Failure: A Systematic Review and Meta-analysis
Int J Oral Maxillofac Implants 2024 Oct 16;39(5)665-673, L Harutyunyan, K Lieuw, B Yang, E Lee, YT Yeh, HH Chen, GH LinFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.