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In this study, the authors investigated antibody titers in 1647 healthcare workers who were vaccinated against SARS-CoV-2 with either the Pfizer-BioNTech or Moderna mRNA vaccine. They found that patients developed higher titers after receiving the Moderna vaccine. This was true across all age ranges and among previously infected and previously uninfected individuals. Those with prior infections did have increased antibody titers following vaccination.
The results of this study suggest that the Moderna mRNA vaccination against SARS-CoV-2 was associated with higher post-vaccination antibody titers than the Pfizer-BioNTech vaccine. The authors suggest that this may be related to higher mRNA load and/or longer duration between the initial injection and booster shot.
The SARS-CoV-2 messenger RNA (mRNA) vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) have each shown more than 90% efficacy in preventing COVID-19 illness but, to our knowledge, humoral immune responses have not been compared directly.