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In this retrospective case–control study, the authors assessed the outcomes of COVID-19 infection in patients with concomitant interstitial lung disease (ILD). Compared with a matched cohort of COVID-19 patients without ILD, they found a fourfold increase in the adjusted odds of death in those with ILD; these patients were more likely to be hospitalized and need intensive care and were less likely to be discharged to home.
This is an important study that confirms what we would likely expect—that patients with ILD do worse with COVID-19 infection as the outcomes highlighted here indicate. These results highlight the importance of counseling patients with ILD regarding safe public health practices and may help inform prognostication.
– Morgan Soffler, MD
This abstract is available on the publisher's site.
Coronavirus disease 2019 (COVID-19) is an international public health emergency. While the prevalence of chronic respiratory disease in patients with COVID-19 has been reportedly low (1.5%), it is associated with increased risk of severe disease and—in chronic obstructive pulmonary disease—increased mortality (1-3). Along with numerous previously reported risk factors for severe COVID-19 (1-6), it has been hypothesized that patients with interstitial lung diseases (ILD) may have poorer outcomes from COVID-19 (7). In this letter, we present the results of a multicenter retrospective case-control study examining outcomes from COVID-19 in patients with pre-existing ILD.