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Published in Bladder Cancer

Expert Opinion / Cases · November 12, 2020

High-grade Urothelial Cancer

Written by
Daniel E. Lage MD, Msc

 

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  • Guru Sonpavde

    Answers to questions: 1. In absence of trial, I would institute docetaxel (without enthusiasm). 2. In presence of FGFR2/3 activating genomic alteration, I would have administered erdafitinib as second-line therapy when patient recurred after radical cystectomy (before pembrolizumab). 3. With current data, no adjuvant therapy is proven, but CHECKMATE274 data are eagerly awaited (Nivolumab improved DFS in all-comers and PD-L1+ patients according to press release). 4. Current optimal systemic therapy for CNS metastases is unclear. Currently, I advise controlling CNS lesions with palliative radiation and institute systemic therapy immediately thereafter. 5. Estimated survival is dismal with CNS metastases (probably worse than liver metastasis, a known poor prognostic factor).


  • Jan 28, 2021

    Pending Moderator approval.
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