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Published in Cardiology

Expert Opinion / Interview · January 27, 2014

Heart Failure With Preserved Ejection Fraction: Part 3

Written by
Barry A. Borlaug MD
Joerg Herrmann MD


Additional Info

  1. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011;32(6):670–679.

  2. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):e147-239.

  3. Pfeffer MA, McKinlay S, Pitt B. Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT). Paper presented at: AHA Scientific Sessions 2013; November 16-20, 2013, Dallas TX. LBCT3-04.

  4. Edelmann F, Wachter R, Schmidt AG, et al. Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction: The Aldo-DHF Randomized Controlled Trial. JAMA. 2013;309(8):781-791.

  5. Cleland JGF, Tendera M, Adamus J, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J. 2006;27(19):2338-2345.

  6. Schwartzenberg S, Redfield MM, From AM, et al. Effects of Vasodilation in Heart Failure With Preserved or Reduced Ejection Fraction: Implications of Distinct Pathophysiologies on Response to Therapy. J Am Coll Cardiol. 2012;59(5):442-451.

  7. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53(21):1925-1932.

  8. Borlaug BA, Redfield MM, Melenovsky V, et al. Longitudinal changes in left ventricular stiffness: a community-based study. Circ Heart Fail. 2013;6(5):944-952.

  9. Kitzman DW, Brubaker PH, Morgan TM, et al. Exercise Training in Older Patients with Heart Failure and Preserved Ejection Fraction: A Randomized, Controlled, Single-Blind Trial. Circ Heart Fail. 2010;3(6):659-667.

  10. Edelmann F, Gelbrich G, Düngen HD, et al. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol. 2011;58(17):1780-1791.

  11. Hummel SL, Seymour EM, Brook RD, et al. Low-sodium DASH diet improves diastolic function and ventricular-arterial coupling in hypertensive heart failure with preserved ejection fraction. Circ Heart Fail. 2013;6(6):1165-1171.

  12. Zakeri R, Chamberlain AM, Roger VL, Redfield MM. Temporal Relationship and Prognostic Significance of Atrial Fibrillation in Heart Failure Patients With Preserved Ejection Fraction: A Community-Based Study. Circulation. 2013;128(10):1085-1093.

  13. Zile MR, Gottdiener JS, Hetzel SJ, et al. Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation. 2011;124(23):2491-2501.

  14. Henkel DM, Redfield MM, Weston SA, et al. Death in heart failure: a community perspective. Circ Heart Fail. 2008;1(2):91-97.

  15. Arbab-Zadeh A, Dijk E, Prasad A, et al. Effect of aging and physical activity on left ventricular compliance. Circulation. 2004;110(13):1799-1805.

  16. Kosmala W, Holland DJ, Rojek A, et al. Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial. J Am Coll Cardiol. 2013;62(15):1330-1338.

Disclosure statements are available on the authors' profiles:

Further Reading