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Published in Brain Cancer

Expert Opinion / Cases · March 16, 2021

Glial/Glioneuronal Neoplasm With BRAF V600E Mutation

Written by
Martin C. Tom MD


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  • Ana Misir Krpan

    Mar 17, 2021

    I would recommend observation and close follow-up.

  • Pieromaria Bianchi

    Mar 19, 2021

    No adjuvant therapy, just periodical MRI control. I would suggest bimonthly MRI at least for the first year

  • Simon Khagi

    Mar 19, 2021

    Serial MRI surveillance every 2-3 months. I would also recommend NGS of the tumor specimen. 

  • Fabio Trippa

    Mar 20, 2021

    I agree with previous comments. At this time I would recommend close follow-up.

  • Minesh Mehta

    Mar 22, 2021

    Glioneuronal tumors occur more commonly in children than in adults, are often lower grade, frequently associated with seizures, and a significant number are characterized by BRAFV600E dysregulation.  The exact management following surgery remains ill-defined; a recent report from St. Jude's suggested that "high-risk" can be defined as diffuse astrocytic histology and/or midbrain/thalamic location" and speculated that post-operative radiotherapy might be beneficial in such a situation.
    This patient does not have such high risk features and observation with surveillance is a very reasonable strategy.

  • ruofan huang

    Mar 24, 2021


  • Amir Anvari

    May 21, 2021

    Close follow up

  • Martin Tom MD

    Martin C. Tom MD

    Jun 25, 2021


    The patient was observed and 2 month MRI brain was read as stable. However, repeat MRI 2 months later showed progression with a larger area of enhancement measuring 18 x 16 x 16 mm with increased rCBV, without significant surrounding edema. How would you proceed with management now?

  • Dron Gauchan

    Nov 28, 2022

    You should probably use Braf and Mek inhibitors

  • Jun 24, 2024

    Pending Moderator approval.

Further Reading