We have detected that you are using an Ad Blocker.
PracticeUpdate is free to end users but we rely on advertising to fund our site. Please consider supporting PracticeUpdate by whitelisting us in your ad blocker.
We have sent a message to the email address you have provided, . If this email is not correct, please update your settings with your correct address.
The email address you provided during registration, , does not appear to be valid. Please update your settings with a valid address before to continue using PracticeUpdate.
Please provide your AHPRA Number to ensure that you are given the correct level of access to our site.
featured
Published in Brain Cancer

Expert Opinion / Cases · March 16, 2021

Glial/Glioneuronal Neoplasm With BRAF V600E Mutation

Written by
Martin C. Tom MD

 

Discuss This item Follow

No comments yet, be the first to start the discussion!

  • Ana Misir Krpan

    I would recommend observation and close follow-up.


  • Pieromaria Bianchi

    No adjuvant therapy, just periodical MRI control. I would suggest bimonthly MRI at least for the first year


  • Simon Khagi

    Serial MRI surveillance every 2-3 months. I would also recommend NGS of the tumor specimen.


  • Fabio Trippa

    I agree with previous comments. At this time I would recommend close follow-up.


  • Minesh Mehta

    Glioneuronal tumors occur more commonly in children than in adults, are often lower grade, frequently associated with seizures, and a significant number are characterized by BRAFV600E dysregulation. The exact management following surgery remains ill-defined; a recent report from St. Jude's suggested that "high-risk" can be defined as diffuse astrocytic histology and/or midbrain/thalamic location" and speculated that post-operative radiotherapy might be beneficial in such a situation. This patient does not have such high risk features and observation with surveillance is a very reasonable strategy.


  • ruofan huang

    observation


  • May 15, 2021

    Pending Moderator approval.
    Delete

Further Reading