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In this review, the author discusses the pathophysiology of gastric emptying abnormalities in people with diabetes. The impact of metabolic changes on gastric emptying and the spectrum of gastric emptying abnormalities, both transient and persistent, are reviewed.
Delayed and rapid gastric emptying can be associated with similar symptoms. Delayed gastric emptying potentially leads to difficulty in glucose control and rapid gastric emptying to progression of diabetes. The impact of management of gastric emptying disorders on control of dysglycemia is considered.
Persistent gastric emptying problems require diagnosis and management. Postprandial dyspepsia and impaired plasma glucose regulation are commonly thought to be due to delayed emptying but can also be due to rapid emptying. Therapy must address whether emptying is delayed or rapid.