Platelet-rich plasma (PRP) shows promise as an androgenetic alopecia (AGA) treatment.
Conduct a randomized placebo-controlled split-scalp study to investigate PRP's effects on hair regrowth and thickness.
35 study participants with AGA had two 7.6-centimeter x 7.6-centimeter squares tattooed on their scalps. Areas were randomly assigned to intradermal injection with PRP or saline. Subjects underwent three monthly treatment sessions with evaluation three months after final treatment.
Hair density in the PRP-treated area was significantly increased compared to baseline at all visits. At the final assessment, hair density in PRP-treated areas increased from 151 ± 39.82 hairs/cm2 at baseline to 170.96 ± 37.14 hairs/cm2, a mean increase of approximately 20 hairs/cm2 (p < 0.05). However, hair density in placebo-treated areas also increased from 151.04 ± 41.99 hairs/cm2 to 166.72 ± 37.13 hairs/cm2 (p < 0.05). There was no significant difference in hair density change between the two groups (p > 0.05). No serious adverse events were reported.
Possible PRP diffusion due to split-scalp study design as well as microinjections causing micro-injury to both sides.
PRP may have benefit in increasing hair density.