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Published in Renal Cell Carcinoma

Expert Opinion / Cases · April 28, 2015

Evaluation for Third Line Therapy

Written by
Heather R Greene MSN, FNP, AOCNP

 

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Heather Greene MSN, FNP, AOCNP

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  • Bradley Somer MD

    Bradley G. Somer MD

    Apr 29, 2015

    This is a patient who unfortunately is progressing rapidly on mTOR inhibitors. We now know from the INTORSECT study that despite the hypothesis, Torisel is probably less beneficial in second line then we thought, as sorafenib yielded better survival (http://www.practiceupdate.com/c/5879/48/1). Unless there was a contraindication to giving either everolimus or axitinib, would probably have steered away from that course. Thus, under the current circumstances of coming off of an mTOR inhibitor strategy, the standard practice would be to give axitinib given great prior response to VEGF inhibitors and the AXIS trial (http://www.practiceupdate.com/c/3182/48/1). Another consideration is clinical trial availability, possibly with an immune checkpoint inhibitor. 

  • Apr 23, 2024

    Pending Moderator approval.
    Delete

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