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Efficacy of Vitamin D Supplementation in Patients With Dry Eye Disease
TAKE-HOME MESSAGE
- This systematic review and meta-analysis of eight studies reporting the effect of vitamin D supplementation on dry eye disease (DED) evaluated the outcomes of oral, intramuscular, and buccal spray delivery and found that oral delivery resulted in significantly better improvement in DED signs (Schirmer's test results, tear film break-up time, and degree of lid hyperemia) and symptoms (Ocular Surface Disease Index).
- These findings suggest that oral vitamin D supplementation may reduce the signs and symptoms of DED.
abstract
This abstract is available on the publisher's site.
Access this abstract now Full Text Available for ClinicalKey SubscribersPURPOSE
Vitamin D (VD) is a vitamin with anti-inflammatory and immunomodulatory effects. Several studies have shown that VD deficiency is associated with the incidence and severity of dry eye disease (DED) in humans. This meta-analysis compared signs and symptoms in patients with DED before and after VD supplementation.
METHODS
Ten databases (PubMed, Cochrane, Web of science, Ovid, Embase, Scopus, CNKI, CSTJ, Wanfang, Sinomed) and four clinical trials registry websites (ISRCTN, CT, ICTRP, ICH GCP) were searched for studies on the efficacy of VD supplement in patients with DED that were published up to 2023 January. A total of 8 studies with 439 cases were included. Two reviewers independently assessed the quality of the literature and extracted data to calculate standard mean differences (SMD) for the Schirmer's test (SH test), tear film break-up time (TBUT), corneal fluorescein staining scores (CFSS, Oxford Scale, 0-5), lid hyperemia, ocular surface disease index (OSDI), and visual analogue pain scale (VAS).
RESULTS
The analysis showed that VD supplementation improved tear production (SMD 1.43, 95% CI 0.81, 2.05, p = 0.000) and tear film stability (SMD 1.19, 95% CI 0.83, 1.55, p = 0.000) and reduced lid hyperemia (SMD -0.71, 95% CI -1.09, -0.32, p = 0.000) and OSDI (SMD -1.10, 95% CI -1.45, -0.74, p = 0.000), which is effective in alleviating the signs and symptoms of DED.
CONCLUSIONS
VD supplementation could be an adjuvant treatment to alleviate the signs and symptoms of dry eye in the future. However, further studies regarding its most appropriate administration and dosage need to be conducted.
Additional Info
The efficacy of vitamin D supplementation in dry eye disease: A systematic review and meta-analysis
Cont Lens Anterior Eye 2024 Jul 17;[EPub Ahead of Print], Z Chen, C Zhang, J Jiang, J Ouyang, D Zhang, T Chen, Y Chu, K HuFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.