Efficacy and Safety of Chemical Peels for the Treatment of Patients With Melasma
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND
Melasma is a common chronic, relapsing pigmentary disorder that causes psychological impact. Chemical peels are a well-known therapeutic modality used for accelerating the treatment of melasma.
OBJECTIVE
To review the published evidence on the efficacy and safety of chemical peels in the treatment of melasma.
METHODS
A systematic review was done. A meta-analysis could not be done due to the heterogeneity of data.
RESULT
The authors conducted a PubMed search and included prospective case series of more than 10 cases and randomized controlled trials (RCTs) that have studied the safety and/or efficacy of chemical peel in melasma. Out of 24 studies, 9 were clinical/comparative trials and 15 were RCTs. The total sample size was 1,075. The duration of the study varied from 8 to 36 weeks. Only 8 studies were split face. All studies used self-assessment, physician global assessment, and Melasma Area and Severity Index (MASI) for quantifying the results. Glycolic acid was found to be the most safe and effective in melasma.
CONCLUSION
Chemical peels were found to be safe and effective in the management of melasma.
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Additional Info
Chemical Peels for Melasma: A Systematic Review
Dermatol Surg 2024 Mar 26;[EPub Ahead of Print], R Sarkar, R LakhaniFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.