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Published in Advanced Melanoma

Expert Opinion / Cases · February 15, 2021

Disease Progression of Metastatic Melanoma on Nivolumab Monotherapy

Written by
Viola Franke MD


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  • Peter Kamen

    ipi and nivo or try a nivo and lag3 phase 3 trial

  • Galina Kharkevich

    No information on BRAF status. Ipi+Nivo. If BRAFpositive BRAF/MEKi is also possible

  • Mikhail Abramov

    use of combination BRAFi + MEKi possible

  • Rosane JohnsaoJohnsson n

    ipi and nivo clinical trial if possible inhibitor BRAF and MEK

  • Alexander van Akkooi

    I think everybody has suggested proven good therapeutic options in this case. Clinical trial is always an option, if you have one open at your site for such a patient. Having said this, we don't actually know what is the best 2nd line treatment after failing adjuvant anti-PD-1 or first line anti-PD-1. There are no prospective randomized trials looking at BRAF/MEK, IPI or IPI/NIVO in this situation. From some retrospective series, IPI/NIVO seems superior to IPI alone. BRAF/MEK obviously also an option, but only for those with a BRAF mutation.

  • Sep 21, 2021

    Pending Moderator approval.

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