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In this review and combined analysis of four trials of COVID-19 patients, the authors assessed the association of D-dimer values with the severity of COVID-19. In aggregate, D-dimer values were considerably higher in those with severe disease than in those whose disease was not severe (weighted mean difference, 2.97 mg/L).
Elevated D-dimer levels appear to be associated with the severity of COVID-19 infection.
– Eric Fountain, MD, MA
This abstract is available on the publisher's site.
A new infective outbreak, sustained by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and defined coronavirus disease 2019 (COVID-19), is now spreading all around the world. The clinical course of this respiratory disease is complicated in up to 15% of infected patients by onset of interstitial pneumonia, evolving toward acute respiratory distress syndrome needing mechanical ventilation or admission to the intensive care unit (ICU), and is also often accompanied by multiorgan failure. Since there is now incontrovertible evidence that laboratory hemostasis provides an essential contribution to decision-making and care of the vast majority of human pathologies, we aimed to explore here whether increased D-dimer values—which are a frequent occurrence in patients with COVID-19—may be associated with disease severity.