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The CytoSorb filter device, which has been developed and approved in Europe, is currently being trialed in the United States to treat cytokine storm. This is a case report in which this device was used for the management of severe COVID-19 in a 51-year-old man with ARDS. The device was utilized starting on day 11 of hospitalization. He also received azithromycin, hydroxychloroquine, tocilizumab, and convalescent plasma during his hospitalization. He had a protracted hospitalization but was eventually discharged to rehab on hospital day 60.
CytoSorbents’ filters have a potentially interesting mechanism of action in combating severe COVID-19 disease. More research within the constraints of a rigorous clinical trial is needed as it is unclear from this case report the impact of the filter on this patient's clinical course.
– Kolene E. Bailey, MD
This abstract is available on the publisher's site.
COVID-19 is a pandemic that has affected not only the United States, but the entire world. The impact it has had has overwhelmed the entire healthcare system, from the unknown carrier status, poor testing capabilities to hospitals running out of ventilators for severely ill patients. There has been a variety of potential treatment modalities for the various forms of illness ranging from asymptomatic carriers to the ventilated ICU patients. These include anti-inflammatory medications, antibiotics, immune-modulators, convalescent plasma, and others. The cytokine storm that inflicts some patients can be devastating to the vital organs of the human body in the form of acute respiratory distress syndrome (ARDS), renal failure, coagulopathy, and death. Cytosorbents® cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy.