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In this prospective randomized trial of 139 patients with obesity (mean weight, 88.2 kg), time-restricted eating (between 8 AM–4 PM) combined with daily calorie restriction was not associated with significantly greater weight reductions at 12-month follow-up compared with daily calorie restriction alone (–8.0 kg vs –6.3 kg; net difference, –1.8 kg). Improvements were observed for waist circumference, body mass index, body fat mass, body lean mass, blood pressure, and metabolic risk factors, without between-group differences.
These results highlight that, among patients with obesity, a weight loss regimen of time-restricted eating combined with daily calorie restriction was not more beneficial than daily calorie restriction alone.
The long-term efficacy and safety of time-restricted eating for weight loss are not clear.
We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal per day for women. The primary outcome was the difference between the two groups in the change from baseline in body weight; secondary outcomes included changes in waist circumference, body-mass index (BMI), amount of body fat, and measures of metabolic risk factors.
Of the total 139 participants who underwent randomization, 118 (84.9%) completed the 12-month follow-up visit. The mean weight loss from baseline at 12 months was -8.0 kg (95% confidence interval [CI], -9.6 to -6.4) in the time-restriction group and -6.3 kg (95% CI, -7.8 to -4.7) in the daily-calorie-restriction group. Changes in weight were not significantly different in the two groups at the 12-month assessment (net difference, -1.8 kg; 95% CI, -4.0 to 0.4; P = 0.11). Results of analyses of waist circumferences, BMI, body fat, body lean mass, blood pressure, and metabolic risk factors were consistent with the results of the primary outcome. In addition, there were no substantial differences between the groups in the numbers of adverse events.
Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction. (Funded by the National Key Research and Development Project [No. 2018YFA0800404] and others; ClinicalTrials.gov number, NCT03745612.).