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The authors, from various centers in Madrid, compared 79 consecutive patients who tested positive for COVID-19 via polymerase chain reaction (PCR) with 40 patients who tested positive for influenza via a PCR test. They report that almost 40% of COVID-19–positive patients had smell and/or taste disturbances compared with patients with influenza (12.5%), that they were significantly younger compared with COVID-19 patients without smell and/or taste disturbances, and that these disturbances usually had an acute onset. The authors suggest that these symptoms could help in self-assessment as well as self-isolation as testing and self-isolation recommendations evolve during this pandemic.
This is a small study when compared with the prevalence of this disease; nevertheless, it provides some value to differentiate symptoms of COVID-19 from influenza, especially as the latter will become more prevalent during fall and winter.
– Omar Iqbal Khan, MD
This abstract is available on the publisher's site.
Specific respiratory tract infections, including COVID-19, may cause smell and/or taste disorders (STDs) with increased frequency. The aim was to determine whether new-onset STDs are more frequent amongst COVID-19 patients than influenza patients.
This was a case-control study including hospitalized patients of two tertiary care centres. Consecutive patients positive for COVID-19 polymerase chain reaction (cases) and patients positive for influenza polymerase chain reaction (historical control sample) were assessed during specific periods, employing a self-reported STD questionnaire.
Seventy-nine cases and 40 controls were included. No significant differences were found in basal features between the two groups. New-onset STDs were significantly more frequent amongst cases (31, 39.2%) than in the control group (5, 12.5 %) [adjusted odds ratio 21.4 (2.77-165.4, P = 0.003)]. COVID-19 patients with new-onset STDs were significantly younger than COVID-19 patients without STDs (52.6 ± 17.2 vs. 67.4 ± 15.1, P < 0.001). Amongst COVID-19 patients who presented STDs, 22 (70.9%) recalled an acute onset and it was an initial manifestation in 11 (35.5%). Twenty-five (80.6%) presented smell disorders (mostly anosmia, 14, 45.2%) and 28 (90.3%) taste disorders (mostly ageusia, 14, 45.2%). Only four (12.9 %) reported concomitant nasal obstruction. The mean duration of STD was 7.5 ± 3.2 days and 12 patients (40%) manifested complete recovery after 7.4 ± 2.3 days of onset.
New-onset STDs were significantly more frequent amongst COVID-19 patients than influenza patients; they usually had an acute onset and were commonly an initial manifestation. The use of STD assessment in anamnesis as a hint for COVID-19 and to support individuals' self-isolation in the current epidemic context is suggested.
Acute-Onset Smell and Taste Disorders in the Context of COVID-19: A Pilot Multicentre Polymerase Chain Reaction Based Case–Control Study
Eur. J. Neurol. 2020 Apr 22;[EPub Ahead of Print], Á Beltrán-Corbellini, JL Chico-García, J Martínez-Poles, F Rodríguez-Jorge, E Natera-Villalba, J Gómez-Corral, A Gómez-López, E Monreal, P Parra-Díaz, JL Cortés-Cuevas, JC Galán, C Fragola-Arnau, J Porta-Etessam, J Masjuan, A Alonso-Cánovas